Magnesium

Magnesium is one of the most important minerals needed for human health. It keeps all of the other minerals in check, helping to absorb and 'activate' calcium, retain sodium, moderate potassium serum levels, 'activate' and assist Silica, and deliver Sulfur. It plays an important role in carbohydrate metabolism and the upkeep of normal insulin production. Without Magnesium the body wouldn't be able to produce or utilize ATP - the cellular energy required to sustain life, nerves would never stop firing keeping the body in a constant state of pain, and DNA could not replicate or be constructed. As one of the most abundant intercellular minerals, Magnesium oversees the foundation from which the experience of life is built upon.  

Bones and Teeth
Roughly 60% of Magnesium is stored in the bone. Much like Calcium, the Magnesium stored in our bones will be released into the extracellular fluids of the body when Serum levels are low through a process known as resorption. Magnesium is used in the body to create something called apatite crystals, which are basically the minerals that make up solid bone. When bones are formed specialized connective tissue cells referred to as Osteoblasts secrete a gelatinous substance made up of collagen, fibrous protein, and long chain fatty acids. Once this matrix is laid down, minerals like Magnesium and Calcium come to fill the gaps an give structure to the lattice (1). Without enough Magnesium, mineralization would be hampered and so would the integrity of your bones. This lack of integrity if untreated can lead to osteoporosis and stress fractures. (2)

Cell Functioning
Magnesium is the second most abundant cation in the body behind potassium and is involved in over 600 different biological reactions. As one of the main intercellular minerals, Magnesium plays a vital role as a cofactor in a large number of enzymatic reactions. This means it helps with muscle firing, heartbeat, energy production, protein synthesis, insulin management, stress reduction, just to name a few... (3)

Magnesium is involved with energy production through its role in helping to synthesis ADP and phosphorus as to make ATP (what gives your body energy). ATP must be bonded to a Magnesium ion in order to become biologically active. What is often referred to as ATP is in most cases Mg-ATP.  ATP is used in every cell of the body, everything from DNA and RNA synthesis to nerve firing. Mg is also used to help stabilizes the structures of cells, DNA, and other larger proteins. If ATP production is ever halted your body will die. True death happens when Cellular energy can no longer be produced. Magnesium plays an extremely important role in making sure that doesn't happen. (4)

Muscle Relaxation
Since Magnesium is so crucial in the production and usage of cellular energy (ATP), it also means that it plays an important role in allowing your body to relax. When we think of relaxing we probably think of not using energy. But, this is actually backwards to the way your body understands it. When ATP production stops, so does cellular life. If your cells die, you die. When a body dies, it gets stiff (rigamortis).  This is because ATP is actually required to relax muscle contractions.

A muscle contraction is first stimulated by the release of a Calcium ion from a nerve cell. That Caclium ion shifts the charge of the area it is in, stimulating the sodium-potassium pump to turn on, in effect creating a muscle contraction. In order for the muscle cell to relax from contraction, the Calcium ion has to return to the nerve cell and the calcium channels must be closed. This is exactly what Magnesium facilitates, the closure of the calcium channel. This response requires Mg-ATP to occur. So, both energy and Magnesium are present and utilized when the body and its muscles relax. Without healthy levels of Magnesium, ATP production is strained, and muscles stay tense or even cramp while in a resting state.  

Mood
Magnesium has been shown to help regulate the hypothalamic pituitary adrenal axis (HPAA) which is a central substrate of the stress response system. The presence of Mg has been shown to regulate and sedate the activity of the HPAA. The less active this is the lower the body's stress response. 

Studies suggest that Magnesium is also involved in the inhibition of the N-methyl-D-aspartate (NMDA) receptors. One of the brain's main excitatory neurotransmitter is Glutamate. It couples itself with NMDA through Ca+ channels to create an excitatory response that can activate a call to action (fight or flight). Because Magnesium helps to inhibit the receptor activity by closing the Calcium channels of NMDA, there is less availability for glutamate to couple, which results in a lowered anxiety response. Magnesium also acts on mGluR proteins in the brain which play a major role in the regulation of Glutamate. Glutamate and GABA have a complementary relationship, meaning they are opposite in effect. Glutamate is responsible for exciting the nervous system whereas GABA inhibits the excitatory response. Magnesium's effect on mGluR is to help inhibit the release of Glutamate. Less Glutamate equates to a higher availability of GABA in the brain and ultimately a calmer state of being. (5)

Mg and Ca
Mg and Ca have an interesting relationship, on one hand, they work together to allow muscle contraction happen. Calcium helps in contracting the muscle cells, while Magnesium helps to relax them. However, Magnesium is what could be called a Calcium antagonist. Meaning it competes with Calcium for certain binding sites. Too much Calcium can lead to cell death making the regulation of calcium of the utmost importance. Having a sufficient level of Mg helps to do this. Adequate Magnesium levels keep other minerals in balance and ultimately lead to cell proliferation as opposed to death. It is extremely difficult to ever have too much Magnesium because the kidneys will happily expel the excess along with any other unneeded salts. This moderating quality of Magnesium can even help cleanse the kidneys, liver, and arteries of calcification. (6) 

Signs and Symptoms of Deficiency:
Magnesium deficiency is rare, but it may affect older people. It can result from excess consumption of alcohol, some health conditions, such as a gastrointestinal disorder, and the use of some medications. Symptoms include:

Loss of appetite
Nausea and vomiting
Fatigue and weakness
Numbness and tingling
Muscle cramps
Seizures
Personality changes
Heart rhythm changes and spasms
Insulin resistance
Metabolic syndrome
Coronary heart disease
Osteoporosis. 
Low calcium
Low potassium levels in the blood

Resources:
​1. https://www.britannica.com/science/bone-formation
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775240/
​3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455825/#bib6
​4.https://pubchem.ncbi.nlm.nih.gov/compound/15126
​5.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/
​6.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455825/#bib6

Immortal Minerals Cell Salt Formula

$25.00 - $200.00

A perfect cell salt formula.

12 Essential Salts supersaturated into living spring water in the ratios that your cells prefer.


Add 1 full dropper to 32oz of water and drink 1-3x a day.

*1oz vials tends to last one individual  3-4 weeks. Time is decreased if shared. 

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